Sam and Dean get themselves admitted to a mental hospital in order to investigate if a monster is attacking patients. But their incarceration pushes them to the breaking point.
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Lovers begin to kill each other in a small town on Valentine's Day. However, when Sam, Dean, and Castiel investigate, they discover people are not just starved for love and Famine, one of the Four Horseman, is fueling their hunger.
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In Bobby's hometown, the dead raise from their graves and take up their family lives where they left off. Sam and Dean suspect something sinister is responsible but Bobby refuses to investigate and they discover his dead wife has returned.
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Dean is ready to give in and allow himself to be used as a vessel by Michael. However, Zachariah is given a second chance and comes up with a plan to turn the Winchesters' family bond against them by recruiting a new vessel.
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Earth's gods gather and trap Sam and Dean in a hotel. While they try to decide what to do, Gabriel tries to keep the gods from engaging in battle. One of the gods turns traitor, endangering everyone and forcing Gabriel to make a decision.
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Crowley contacts Sam and Dean and offers to help them find Pestilence so they can get the third ring and trap Lucifer. They capture the demon in charge of coordinating the Horsemen's activities but Sam realizes the demon is an acquaintance.
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After Bobby and the brothers recover Castiel, they search out Pestilence to stop the distribution of the Croatoan virus. Dean and Crowley go to Chicago where Lucifer is using Death to create a storm that will wipe out three million people.
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Sam is released from hell and tries to convince Dean to rejoin him in fighting evil. To help persuade him, Sam introduces Dean to a new family led by their grandfather Samuel.
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ABOUT
Twenty-six years ago, Sam Winchester and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father John raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America ... and he taught them how to kill it.
